5-HTP or 5-Hydroxytryptophan is a chemical by-product of the protein building block L-tryptophan. 5 HTP acts to boost serotonin levels. Serotonin is a neurotransmitter, a type of chemical that helps relay signals from one area of the brain to another. Although serotonin is manufactured in the brain, where it performs its primary functions, some 90% of our serotonin supply is found in the digestive tract and in blood platelets.
Our brain uses serotonin to regulate Mood and appetite. A, deficiency in effective seratonin can lead to reduced mental performance and mood disorders. 5-HTP is not found in foods we eat. Our 5-HTP is made from the seeds of the African plant Griffonia simplicifolia. Many People are increasingly turning to these supplements to help boost their moods, regulate their appetites, and help with muscular discomfort.
Consult your primary care provider or physician before taking this supplement.
Cognitive Health (Anxiety & Depression):
Study 1: In 1980, a study of ninety-nine therapy-resistant depressive out-patients treated with 5-HTP, in combination with the peripheral decarboxylase inhibitor, Carbidopa, led to n “astonishing” recovery, without side effects in approximately 50 % of the trial population.
Study 2: Response to standard treatments for major depressive disorders (MDD) is especially low, particularly amongst the female population, and augmentation of therapy with other ingredients is of interest to clinicians. A open label clinical study published in 2017 assessed the benefit of a combination of creatine and 100 mg of 5-HTP twice daily, in combination with already approved SSRIs or SNRIs (selective norepinephrine reuptake inhibitors). Supplementation was given for 8 weeks, with 4 weeks of post-treatment follow up, with the primary endpoint being a change in mean HAM-D (Hamilton Depression Rating scale) scores. The results show that the addition of 5-HTP and creatine led to a mean 60% decrease in HAM-D scores.
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